Interoperability is the ability of different systems, devices, applications or products to connect and communicate in a coordinated way, without effort from the end user. Over the last several decades, considerable effort has been placed by software developers, those responsible for managing supply chains and manufacturing, and throughout the business community more broadly to enhance interoperability and reduce the often difficult process of communicating between systems. Blockchain technology has recently been put forward as a tool that can help accelerate these efforts while also enhancing the overall security and transparency of the system. Some initial projects have been developed towards this end, but broad adoption has yet to occur. This is due in large part both to being very early on in the development of the technology and to some broader challenges and concerns that will be discussed in what follows.